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Immune checkpoint inhibitor–induced inflammatory arthritis as a model of autoimmune arthritis
Author(s) -
Cappelli Laura C.,
Thomas Mekha A.,
Bingham Clifton O.,
Shah Ami A.,
Darrah Erika
Publication year - 2020
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12832
Subject(s) - arthritis , immunology , inflammatory arthritis , medicine , immune system , rheumatoid arthritis , cancer
The development of inflammatory arthritis in patients receiving immune checkpoint inhibitor therapy is increasingly recognized due to the growing use of these drugs for the treatment of cancer. This represents an important opportunity not only to define the mechanisms responsible for the development of this immune‐related adverse event and to ultimately predict or prevent its development, but also to provide a unique window into early events in the development of inflammatory arthritis. Knowledge gained through the study of this patient population, for which the inciting event is known, could shed light into the pathogenesis of autoimmune arthritis. This review will highlight the clinical and immunologic features of these entities to define common elements for future study.