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Future prospects for CD8 + regulatory T cells in immune tolerance
Author(s) -
Flippe Léa,
Bézie Séverine,
Anegon Ignacio,
Guillonneau Carole
Publication year - 2019
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12812
Subject(s) - biology , phenotype , cd8 , immune tolerance , immune system , immunology , computational biology , genetics , gene
CD8 + Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4 + Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss the biology, development and induction of CD8 + Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.