Future prospects for CD8 +  regulatory T cells in immune tolerance | Zendy

Flippe Léa | Zendy; Bézie Séverine | Zendy; Anegon Ignacio | Zendy; Guillonneau Carole | Zendy

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Future prospects for CD8 + regulatory T cells in immune tolerance

Author(s) -

Flippe Léa,

Bézie Séverine,

Anegon Ignacio,

Guillonneau Carole

Publication year - 2019

Publication title -

immunological reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.839

H-Index - 223

eISSN - 1600-065X

pISSN - 0105-2896

DOI - 10.1111/imr.12812

Subject(s) - cd8 , phenotype , biology , immune system , immune tolerance , immunology , computational biology , genetics , gene

CD8 + Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4 + Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss the biology, development and induction of CD8 + Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.

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