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Regulation of immune system development and function by Cbl‐mediated ubiquitination
Author(s) -
Li Xin,
Gong Liying,
Gu Hua
Publication year - 2019
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12789
Subject(s) - ubiquitin , biology , immune system , microbiology and biotechnology , f box protein , function (biology) , context (archaeology) , ubiquitin ligase , transcription factor , ubiquitins , immunology , genetics , gene , paleontology
Ubiquitination is a form of posttranslational protein modification that affects the activity of target proteins by regulating their intracellular degradation, trafficking, localization, and association with other regulators. Recent studies have placed protein ubiquitination as an important regulatory mode to control immune system development, function, and pathogenesis. In this review, we will mainly update the research progress from our laboratory on the roles of the Cbl family of E3 ubiquitin ligases in the development and function of lymphocytes and non‐lymphoid cells. In addition, we will highlight our current understanding of the mechanisms used by this family of proteins, especially Cbl and Cbl‐b, to co‐ordinately regulate the function of various receptors and transcription factors in the context of immune regulation and diseases.