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T‐cell positioning by chemokines in autoimmune skin diseases
Author(s) -
Richmond Jillian M.,
Strassner James P.,
Essien Kingsley I.,
Harris John E.
Publication year - 2019
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12762
Subject(s) - chemokine , immunology , autoimmune disease , biology , disease , inflammation , function (biology) , medicine , microbiology and biotechnology , pathology , antibody
Summary Autoimmune skin diseases are complex processes in which autoreactive cells must navigate through the skin tissue to find their targets. Regulatory T cells in the skin help to mitigate autoimmune inflammation and may in fact be responsible for the patchy nature of these conditions. In this review, we will discuss chemokines that are important for global recruitment of T cell populations to the skin during disease, as well as signals that fine‐tune their localization and function. We will describe prototypical disease responses and chemokine families that mediate these responses. Lastly, we will include an overview of chemokine‐targeting drugs that have been tested as new treatment strategies for autoimmune skin diseases.