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Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches
Author(s) -
Haberman Ann M.,
Gonzalez David G.,
Wong Patrick,
Zhang Tingting,
Kerfoot Steven M.
Publication year - 2019
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12731
Subject(s) - biology , coevolution , context (archaeology) , niche , germinal center , stromal cell , ecological niche , evolutionary biology , genetics , b cell , ecology , cancer research , paleontology , habitat , antibody
Summary Throughout the developing GC response, B cell survival and fate choices made at the single cell level are dependent on signals received largely through interactions with other cells, often with cognate T cells. The type of signals that a given B cell can encounter is dictated by its location within tissue microarchitecture. The focus of this review is on the initiation and evolution of the GC response at the earliest time points. Here, we review the key factors influencing the progression of GC B cell differentiation that are both stage and context dependent. Finally, we describe the coevolution of niches within and surrounding the GC that influence the outcome of the GC response.