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Spatial and temporal coordination of antiviral responses by group 1 ILC s
Author(s) -
Adams Nicholas M.,
Sun Joseph C.
Publication year - 2018
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12710
Subject(s) - biology , context (archaeology) , innate immune system , population , immunology , viral infection , microbiology and biotechnology , virology , immune system , virus , paleontology , demography , sociology
Summary Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC 1s that are engaged during pathogen invasion. We are only beginning to understand the context‐dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic perturbations. With a focus on viral infection, this review highlights the organization and regulation of spatially and temporally distinct waves of NK cell and ILC 1 responses that collectively serve to achieve optimal viral control.