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Premium Mathematical modeling of within‐host Zika virus dynamics
Author(s)
Best Katharine,
Perelson Alan S
Publication year2018
Publication title
immunological reviews
Resource typeJournals
PublisherBlackwell Publishing
Summary Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. Here, we outline a mathematical modeling approach for analyzing the within‐host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.
Subject(s)biology , computational biology , genetics , host (biology) , immune system , immunology , outbreak , virology , virus , zika virus
Language(s)English
SCImago Journal Rank6.839
H-Index223
eISSN1600-065X
pISSN0105-2896
DOI10.1111/imr.12687

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