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iReceptor: A platform for querying and analyzing antibody/B‐cell and T‐cell receptor repertoire data across federated repositories
Author(s) -
Corrie Brian D.,
Marthandan Nishanth,
Zimonja Bojan,
Jaglale Jerome,
Zhou Yang,
Barr Emily,
Knoetze Nicole,
Breden Frances M. W.,
Christley Scott,
Scott Jamie K.,
Cowell Lindsay G.,
Breden Felix
Publication year - 2018
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12666
Subject(s) - metadata , computer science , workflow , gateway (web page) , data sharing , medicine , computational biology , data mining , world wide web , database , biology , alternative medicine , pathology
Summary Next‐generation sequencing allows the characterization of the adaptive immune receptor repertoire ( AIRR ) in exquisite detail. These large‐scale AIRR ‐seq data sets have rapidly become critical to vaccine development, understanding the immune response in autoimmune and infectious disease, and monitoring novel therapeutics against cancer. However, at present there is no easy way to compare these AIRR ‐seq data sets across studies and institutions. The ability to combine and compare information for different disease conditions will greatly enhance the value of AIRR ‐seq data for improving biomedical research and patient care. The iR eceptor Data Integration Platform (gateway.ireceptor.org) provides one implementation of the AIRR Data Commons envisioned by the AIRR Community (airr‐community.org), an initiative that is developing protocols to facilitate sharing and comparing AIRR ‐seq data. The iR eceptor Scientific Gateway links distributed (federated) AIRR ‐seq repositories, allowing sequence searches or metadata queries across multiple studies at multiple institutions, returning sets of sequences fulfilling specific criteria. We present a review of the development of iR eceptor, and how it fits in with the general trend toward sharing genomic and health data, and the development of standards for describing and reporting AIRR ‐seq data. Researchers interested in integrating their repositories of AIRR ‐seq data into the iR eceptor Platform are invited to contact support@ireceptor.org .