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ILC 2 memory: Recollection of previous activation
Author(s) -
MartinezGonzalez Itziar,
Ghaedi Maryam,
Steer Catherine A.,
Mathä Laura,
Vivier Eric,
Takei Fumio
Publication year - 2018
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12643
Subject(s) - recall , immunological memory , immunology , innate immune system , myeloid cells , biology , immunity , immune system , neuroscience , psychology , cognitive psychology
Summary Immunological memory, traditionally thought to belong to T and B cells, has now been extended to innate lymphocytes, including NK cells and ILC 2s, myeloid cells such as macrophages, also termed “trained immunity” and more recently to epithelial stem cells. In this review, we discuss the mechanisms underlying memory generation on ILC 2s and speculate about their potential role in human allergic diseases, such as asthma. Moreover, we examine the relevance of the spontaneous ILC 2 activation in the lung during the neonatal period in order to efficiently respond to stimuli later in life. These “training” of neonatal ILC 2s may have an impact on the generation of memory ILC 2s in the adulthood.