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Memory vs memory‐like: The different facets of CD 8 + T‐cell memory in HCV infection
Author(s) -
Hofmann Maike,
Wieland Dominik,
Pircher Hanspeter,
Thimme Robert
Publication year - 2018
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12642
Subject(s) - memory cell , biology , cd8 , immunology , chronic infection , virology , memory t cell , cytotoxic t cell , t cell , virus , antigen , hepatitis c virus , effector , immune system , genetics , physics , transistor , quantum mechanics , voltage , in vitro
Summary Memory CD 8 + T cells are essential in orchestrating protection from re‐infection. Hallmarks of virus‐specific memory CD 8 + T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen‐independent survival. Growing evidence reveals that even chronic infection does not preclude virus‐specific CD 8 + T‐cell memory formation. However, whether this kind of CD 8 + T‐cell memory that is established during chronic infection is indeed functional and provides protection from re‐infection is still unclear. Human chronic hepatitis C virus infection represents a unique model system to study virus‐specific CD 8 + T‐cell memory formation during and after cessation of persisting antigen stimulation.