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Metabolic regulation of macrophage phenotype and function
Author(s) -
Saha Shilpi,
Shalova Iri.,
Biswas Subhra K.
Publication year - 2017
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12603
Subject(s) - phenotype , biology , epigenetics , function (biology) , epigenesis , transcriptome , macrophage , genetics , gene , gene expression , dna methylation , in vitro
Summary Studies in the last 20 years have given us a remarkable insight into the functional and phenotypic diversity of macrophages which reflects their integral role in host defence, homeostasis and pathogenesis. Mouse genetics, transcriptomic and epigenetic studies have provided an ontogenic and molecular perspective to the phenotypic diversity of these cells. Recently, metabolic studies have revealed the crucial role of metabolism and metabolites in shaping the phenotype and function of macrophages. Evidence pertaining to this aspect will be reviewed here.