Premium
Interplay of innate lymphoid cells and the microbiota
Author(s) -
Britanova Liudmila,
Diefenbach Andreas
Publication year - 2017
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12580
Subject(s) - innate lymphoid cell , biology , innate immune system , immune system , host (biology) , immunology , microbiology and biotechnology , ecology
Summary Innate lymphoid cells ( ILC ) are a recently identified group of innate lymphocytes that are preferentially located at barrier surfaces. Barrier surfaces are in direct contact with complex microbial ecosystems, collectively referred to as the microbiota. It is now believed that the interplay of the microbiota with host components (i.e. epithelial cells and immune cells) promotes host fitness by regulating organ homeostasis, metabolism, and host defense against pathogens. In this review, we will give an overview of this multifaceted interplay between ILC and components of the microbiota.