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Host‐microbiota interactions and adaptive immunity
Author(s) -
McCoy Kathy D.,
Ronchi Francesca,
Geuking Markus B.
Publication year - 2017
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12575
Subject(s) - biology , acquired immune system , immune system , immunity , compartmentalization (fire protection) , immunology , innate immune system , mucosal immunology , antibody , biochemistry , enzyme
Summary All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure compartmentalization, the microbiota is also able to induce robust adaptive immunity. In this review, we discuss the interplay between the microbiota and the adaptive immune system, with a focus on the induction of mucosal and systemic antibody responses and newly defined roles of maternal antibodies. We also highlight recent studies that aim to decipher microbial antigen‐specificity of the T‐cell compartment.