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Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells
Author(s) -
Palomares Oscar,
Akdis Mübeccel,
MartínFontecha Mar,
Akdis Cezmi A.
Publication year - 2017
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12555
Subject(s) - immunology , immune system , immune tolerance , regulatory b cells , allergy , allergen , immunotherapy , regulatory t cell , population , medicine , peripheral tolerance , disease , antigen , biology , t cell , interleukin 10 , il 2 receptor , environmental health
Summary Allergy is a major public health problem with a high socio‐economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen‐specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen‐specific immunotherapy ( AIT ) and healthy immune response during high‐dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease‐modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen‐specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune‐tolerance‐related diseases.