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The complement factor H‐related proteins
Author(s) -
MedjeralThomas Nicholas,
Pickering Matthew C.
Publication year - 2016
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12477
Subject(s) - complement system , complement (music) , factor h , regulator , biology , context (archaeology) , immunology , alternative complement pathway , complement component 2 , complement factor i , antibody , genetics , phenotype , paleontology , complementation , gene
Summary The role of the complement factor H‐related ( FHR ) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR proteins appear to promote C3 activation. These data have important implications for understanding complement‐mediated diseases because, depending on the context, the balance between the actions of factor H and the FHR proteins determines the degree of complement activation.