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Innate immune mediators in cancer: between defense and resistance
Author(s) -
Berraondo Pedro,
Minute Luna,
Ajona Daniel,
Corrales Leticia,
Melero Ignacio,
Pio Ruben
Publication year - 2016
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12464
Subject(s) - innate immune system , immune system , biology , immunology , tumor microenvironment , immunotherapy , innate lymphoid cell , cancer , cancer immunotherapy , acquired immune system , inflammation , cancer research , genetics
Summary Chronic inflammation in the tumor microenvironment and evasion of the antitumor effector immune response are two of the emerging hallmarks required for oncogenesis and cancer progression. The innate immune system not only plays a critical role in perpetuating these tumor‐promoting hallmarks but also in developing antitumor adaptive immune responses. Thus, understanding the dual role of the innate system in cancer immunology is required for the design of combined immunotherapy strategies able to tackle established tumors. Here, we review recent advances in the understanding of the role of cell populations and soluble components of the innate immune system in cancer, with a focus on complement, the adapter molecule Stimulator of Interferon Genes, natural killer cells, myeloid cells, and B cells.