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Neutrophils and the inflammatory tissue microenvironment in the mucosa
Author(s) -
Campbell Eric L.,
Kao Daniel J.,
Colgan Sean P.
Publication year - 2016
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12456
Subject(s) - inflammation , biology , immunology , gastrointestinal tract , function (biology) , in vivo , microbiology and biotechnology , pathology , medicine , biochemistry
Summary The interaction of neutrophils ( PMN s) and epithelial cells are requisite lines of communication during mucosal inflammatory responses. Consequences of such interactions often determine endpoint organ function, and for this reason, much interest has developed around defining the constituents of the tissue microenvironment of inflammatory lesions. Physiologic in vitro and in vivo models have aided in the discovery of components that define the basic inflammatory machinery that mold the inflammatory tissue microenvironment. Here, we will review the recent literature related to the contribution of PMN s to molding of the tissue microenvironment, with an emphasis on the gastrointestinal ( GI ) tract. We focus on endogenous pathways for promoting tissue homeostasis and the molecular determinants of neutrophil–epithelial cell interactions during ongoing inflammation. These recent studies highlight the dynamic nature of these pathways and lend insight into the complexity of treating mucosal inflammation.