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Dynamics of the membrane–cytoskeleton interface in MHC class II ‐restricted antigen presentation
Author(s) -
Bretou Marine,
Kumari Anita,
Malbec Odile,
Moreau Hélène D.,
Obino Dorian,
Pierobon Paolo,
Randrian Violaine,
Sáez Pablo J.,
LenDuménil AnaMaria
Publication year - 2016
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12429
Subject(s) - biology , cytoskeleton , major histocompatibility complex , immunology , antigen , antigen presentation , presentation (obstetrics) , class (philosophy) , microbiology and biotechnology , cell , t cell , immune system , genetics , medicine , computer science , radiology , artificial intelligence
Summary Antigen presentation refers to the ability of cells to show MHC ‐associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide‐derived antigens that are internalized by endocytosis in antigen‐presenting cells ( APC s). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APC s: dendritic cells ( DC s) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC –T cell interactions. We further discuss how the interaction between APC ‐specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.