Premium
Development of T‐cell tolerance utilizes both cell‐autonomous and cooperative presentation of self‐antigen
Author(s) -
Perry Justin S. A.,
Hsieh ChyiSong
Publication year - 2016
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12403
Subject(s) - antigen presentation , antigen , biology , presentation (obstetrics) , immunology , self tolerance , cell , antigen presenting cell , t cell , computational biology , genetics , medicine , immune system , radiology
Summary The development of T‐cell self‐tolerance in the thymus is important for establishing immune homeostasis and preventing autoimmunity. Here, we review the components of T‐cell tolerance, which includes T‐cell receptor ( TCR ) self‐reactivity, costimulation, cytokines, and antigen presentation by a variety of antigen‐presenting cells ( APC s) subsets. We discuss the current evidence on the process of regulatory T (Treg) cell and negative selection and the importance of TCR signaling. We then examine recent evidence showing unique roles for bone marrow ( BM )‐derived APC s and medullary thymic epithelial cells ( mTEC s) on the conventional and Treg TCR repertoire, as well as emerging data on the role of B cells in tolerance. Finally, we review the accumulating data that suggest that cooperative antigen presentation is a prominent component of T ‐ell tolerance. With the development of tools to interrogate the function of individual APC subsets in the medulla, we have gained greater understanding of the complex cellular and molecular events that determine T‐cell tolerance.