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Surveillance of cell and tissue perturbation by receptors in the LRC
Author(s) -
Trowsdale John,
Jones Des C.,
Barrow Alexander D.,
Traherne James A.
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12314
Subject(s) - receptor , immunoglobulin superfamily , biology , human leukocyte antigen , computational biology , gene , genetics , immune system , microbiology and biotechnology , antigen
Summary The human leukocyte receptor complex ( LRC ) encompasses several sets of genes with a common evolutionary origin and which form a branch of the immunoglobulin superfamily (Ig SF ). Comparisons of LRC genes both within and between species calls for a high degree of plasticity. The drive for this unprecedented level of variation is not known, but it relates in part to interaction of several LRC products with polymorphic human leukocyte antigen ( HLA ) class I molecules. However, the range of other proposed ligands for LRC products indicates a dynamic set of receptors that have adapted to detect target molecules relating to numerous cellular pathways. Several receptors in the complex bind a molecular signature in collagenous ligands. Others detect a variety of motifs relating to pathogens in addition to cellular stress, attesting to the opportunistic versatility of LRC receptors.