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TRAF 3, ubiquitination, and B‐lymphocyte regulation
Author(s) -
Lin Wai W.,
Hostager Bruce S.,
Bishop Gail A.
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12299
Subject(s) - biology , microbiology and biotechnology , signal transduction , ubiquitin , signal transducing adaptor protein , effector , immune system , immunology , genetics , gene
Summary The signaling adapter protein tumor necrosis factor receptor ( TNFR )‐associated factor 3 ( TRAF 3) is both modified by and contributes to several types of ubiquitination events. TRAF 3 plays a variety of context‐dependent regulatory roles in all types of immune cells. In B lymphocytes, TRAF 3 contributes to regulation of signaling by members of both the TNFR superfamily and innate immune receptors. TRAF 3 also plays a unique cell type‐specific and critical role in the restraint of B‐cell homeostatic survival, a role with important implications for both B‐cell differentiation and the pathogenesis of B‐cell malignancies. This review focuses upon the relationship between ubiquitin and TRAF 3, and how this contributes to multiple functions of TRAF 3 in the regulation of signal transduction, transcriptional activation, and effector functions of B lymphocytes.