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Negative regulation of the inflammasome: keeping inflammation under control
Author(s) -
PedrazaAlva Gustavo,
PérezMartínez Leonor,
ValdezHernández Laura,
MezaSosa Karla F.,
AndoKuri Masami
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12294
Subject(s) - inflammasome , inflammation , biology , immunology , inflammatory response , homeostasis , stimulus (psychology) , caspase 1 , neuroscience , microbiology and biotechnology , psychology , psychotherapist
Summary In addition to its roles in controlling infection and tissue repair, inflammation plays a critical role in diverse and distinct chronic diseases, such as cancer, metabolic syndrome, and neurodegenerative disorders, underscoring the harmful effect of an uncontrolled inflammatory response. Regardless of the nature of the stimulus, initiation of the inflammatory response is mediated by assembly of a multimolecular protein complex called the inflammasome, which is responsible for the production of inflammatory cytokines, such as interleukin‐1β ( IL ‐1β) and IL ‐18. The different stimuli and mechanisms that control inflammasome activation are fairly well understood, but the mechanisms underlying the control of undesired inflammasome activation and its inactivation remain largely unknown. Here, we review recent advances in our understanding of the molecular mechanisms that negatively regulate inflammasome activation to prevent unwanted activation in the resting state, as well as those involved in terminating the inflammatory response after a specific insult to maintain homeostasis.