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Bacterial recognition pathways that lead to inflammasome activation
Author(s) -
Storek Kelly M.,
Monack Denise M.
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12289
Subject(s) - inflammasome , biology , lead (geology) , immunology , microbiology and biotechnology , computational biology , inflammation , paleontology
Summary Inflammasomes are multi‐protein signaling platforms that upon activation trigger the maturation of the pro‐inflammatory cytokines, interleukin‐1β ( IL ‐1β) and IL ‐18, and cell death. Inflammasome sensors detect microbial and host‐derived molecules. Here, we review the mechanisms of inflammasome activation triggered by bacterial infection, primarily focusing on two model intracellular bacterial pathogens, Francisella novicida and Salmonella typhimurium . We discuss the complex relationship between bacterial recognition through direct and indirect detection by inflammasome sensors. We highlight regulation mechanisms that potentiate or limit inflammasome activation. We discuss the importance of caspase‐1 and caspase‐11 in host defense, and we examine the downstream consequences of inflammasome activation within the context of bacterial infections.