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MR 1‐restricted mucosal associated invariant T ( MAIT ) cells in the immune response to M ycobacterium tuberculosis
Author(s) -
Gold Marielle C.,
Napier Ruth J.,
Lewinsohn David M.
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12271
Subject(s) - immune system , biology , mycobacterium tuberculosis , immunology , population , intracellular parasite , epitope , intracellular , tuberculosis , major histocompatibility complex , t cell , microbiology and biotechnology , antigen , medicine , environmental health , pathology
Summary The intracellular pathogen M ycobacterium tuberculosis (Mtb) and its human host have long co‐evolved. Although the host cellular immune response is critical to the control of the bacterium information on the specific contribution of different immune cell subsets in humans is incomplete. Mucosal associated invariant T ( MAIT ) cells are a prevalent and unique T‐cell population in humans with the capacity to detect intracellular infection with bacteria including Mtb. MAIT cells detect bacterially derived metabolites presented by the evolutionarily conserved major histocompatibility complex‐like molecule MR 1. Here, we review recent advances in our understanding of this T‐cell subset and address the potential roles for MR 1‐restricted T cells in the control, diagnosis, and therapy of tuberculosis.