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The eukaryotic translation initiation factor eIF 4E in the nucleus: taking the road less traveled
Author(s) -
Osborne Michael J.,
Borden Katherine L. B.
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12240
Subject(s) - eif4e , eukaryotic translation , eukaryotic translation initiation factor 4 gamma , translation (biology) , initiation factor , biology , eif4a1 , myeloid leukemia , eukaryotic initiation factor , computational biology , eif4g , nuclear export signal , genetics , cytoplasm , cancer research , microbiology and biotechnology , gene , cell nucleus , messenger rna
Summary The eukaryotic translation initiation factor eIF 4E is a potent oncogene. Although eIF 4E has traditional roles in translation initiation in the cytoplasm, it is also found in the nucleus, suggesting that it has activities beyond its role in protein synthesis. The road less traveled has been taken to study these nuclear activities and to understand their contribution to the oncogenic potential of eIF 4E. The molecular features and biological pathways underpinning eIF 4E's nuclear mRNA export are described. New classes of eIF 4E regulators have been identified and their relevance to cancer shown. The studies presented here reveal the molecular, biophysical, and structural bases for eIF 4E regulation. Finally, recent clinical work targeting eIF 4E in acute myeloid leukemia patients with ribavirin is discussed. In summary, these findings provide a novel paradigm for eIF 4E function and the molecular basis for targeting it in leukemia patients.