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Targeting the bone marrow microenvironment in multiple myeloma
Author(s) -
Kawano Yawara,
Moschetta Michele,
Manier Salomon,
Glavey Siobhan,
Görgün Güllü T.,
Roccaro Aldo M.,
Anderson Kenneth C.,
Ghobrial Irene M.
Publication year - 2015
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12233
Subject(s) - stromal cell , bone marrow , multiple myeloma , tumor microenvironment , cancer research , malignancy , plasma cell , biology , compartment (ship) , immune system , immunology , pathology , medicine , oceanography , geology
Summary Multiple myeloma ( MM ) is characterized by clonal expansion of malignant plasma cells in the bone marrow ( BM ). Despite the significant advances in treatment, MM is still a fatal malignancy. This is mainly due to the supportive role of the BM microenvironment in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM microenvironment is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a non‐cellular compartment. In this review, we discuss the interaction between the malignant plasma cell and the BM microenvironment and the strategy to target them.