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Intestinal IgA production and its role in host‐microbe interaction
Author(s) -
Gutzeit Cindy,
Magri Giuliana,
Cerutti Andrea
Publication year - 2014
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12189
Subject(s) - biology , immune system , commensalism , immunology , immunoglobulin a , host (biology) , antibody , microbiology and biotechnology , colonization , homeostasis , bacteria , immunoglobulin g , genetics
Summary Complex and diverse communities of bacteria establish mutualistic and symbiotic relationships with the gut after birth. The intestinal immune system responds to bacterial colonization by acquiring a state of hypo‐responsiveness against commensals and active readiness against pathogens. The resulting homeostatic balance involves a continuous dialog between the microbiota and lymphocytes with the intermediation of epithelial and dendritic cells. This dialog causes massive production of immunoglobulin A (IgA), a non‐inflammatory antibody specialized in mucosal protection. Here, we discuss recent advances on the regulation of intestinal IgA responses and their role in host‐microbe interaction.