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Dendritic cell–epithelial cell crosstalk in the gut
Author(s) -
Rescigno Maria
Publication year - 2014
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12181
Subject(s) - immune system , crosstalk , biology , immunology , intraepithelial lymphocyte , microbiology and biotechnology , dendritic cell , immunity , physics , optics
Summary Intestinal epithelial cells are fundamental to maintain barrier integrity and to participate in food degradation and absorption, but they can also decipher signals coming from the outside world and ‘educate’ the immune system accordingly. In particular, they interact with dendritic cells ( DC s) and other intraepithelial immune cells to drive tolerogenic responses under steady state, but they can also release immune mediators to recruit inflammatory cells and to elicit immunity to infectious agents. When these interactions are deregulated, immune disorders can develop. In this review, we discuss some important features of epithelial cells and DC s and their fruitful interactions.