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Contextual functions of antigen‐presenting cells in the gastrointestinal tract
Author(s) -
Grainger John R.,
Askenase Michael H.,
GuimontDesrochers Fanny,
Fonseca Denise Morais da,
Belkaid Yasmine
Publication year - 2014
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12167
Subject(s) - gastrointestinal tract , biology , effector , antigen , immune system , immunology , inflammation , function (biology) , immune tolerance , microbiology and biotechnology , biochemistry
Summary The immune system of the gastrointestinal tract must be tightly regulated to limit pathologic responses toward innocuous antigens while simultaneously allowing for rapid development of effector responses against invading pathogens. Highly specialized antigen‐presenting cell ( APC ) subsets present in the gut play a dominant role in balancing these seemingly disparate functions. In this review, we discuss new findings associated with the function of gut APC s and particularly the contextual role of these cells in both establishing tolerance to orally acquired antigens in the steady state and regulating acute inflammation during infection.