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Induction of transplantation tolerance through regulatory cells: from mice to men
Author(s) -
Ferrer Ivana R.,
Hester Joanna,
Bushell Andrew,
Wood Kathryn J.
Publication year - 2014
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12158
Subject(s) - transplantation , biology , immunology , immune tolerance , immune system , regulatory t cell , cell , t cell , medicine , genetics , il 2 receptor
Summary Organ transplantation results in the activation of both innate and adaptive immune responses to the foreign antigens. While these responses can be limited with the use of systemic immunosuppressants, the induction of regulatory cell populations may be a novel strategy for the maintenance of specific immunological unresponsiveness that can reduce the severity of the detrimental side effects of current therapies. Our group has extensively researched different regulatory T‐cell induction protocols for use as cellular therapy in transplantation. In this review, we address the cellular and molecular mechanisms behind regulatory T‐cell suppression and their stability following induction protocols. We further discuss the use of different hematopoietically derived regulatory cell populations, including regulatory B cells, regulatory macrophages, tolerogenic dendritic cells, and myeloid‐derived suppressor cells, for the induction of transplantation tolerance in light of new clinical trials developing therapies with some of these populations.