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Inflammatory triggers of acute rejection of organ allografts
Author(s) -
Mori Daniel N.,
Kreisel Daniel,
Fullerton James N.,
Gilroy Derek W.,
Goldstein Daniel R.
Publication year - 2014
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12146
Subject(s) - organ transplantation , transplantation , innate immune system , immune system , immunology , inflammation , solid organ , biology , acquired immune system , transplant rejection , graft rejection , medicine
Summary Solid organ transplantation is a vital therapy for end stage diseases. Decades of research have established that components of the adaptive immune system are critical for transplant rejection, but the role of the innate immune system in organ transplantation is just emerging. Accumulating evidence indicates that the innate immune system is activated at the time of organ implantation by the release of endogenous inflammatory triggers. This review discusses the nature of these triggers in organ transplantation and also potential mediators that may enhance inflammation resolution after organ implantation.