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Adoptive immunotherapy for cancer
Author(s) -
Ruella Marco,
Kalos Michael
Publication year - 2014
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12136
Subject(s) - adoptive immunotherapy , adoptive cell transfer , context (archaeology) , immunotherapy , immunology , cell therapy , cancer immunotherapy , immune system , biology , cancer , t cell , cell , paleontology , genetics
Summary Recent clinical success has underscored the potential for immunotherapy based on the adoptive cell transfer ( ACT ) of engineered T lymphocytes to mediate dramatic, potent, and durable clinical responses. This success has led to the broader evaluation of engineered T‐lymphocyte‐based adoptive cell therapy to treat a broad range of malignancies. In this review, we summarize concepts, successes, and challenges for the broader development of this promising field, focusing principally on lessons gleaned from immunological principles and clinical thought. We present ACT in the context of integrating T‐cell and tumor biology and the broader systemic immune response.