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Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton
Author(s) -
Rougerie Pablo,
Miskolci Veronika,
Cox Dianne
Publication year - 2013
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12118
Subject(s) - lamellipodium , chemotaxis , microbiology and biotechnology , phagocytosis , actin , actin remodeling , biology , cytoskeleton , actin cytoskeleton , macrophage , receptor , cell , biochemistry , in vitro
Summary Macrophages are best known for their protective search and destroy functions against invading microorganisms. These processes are commonly known as chemotaxis and phagocytosis. Both of these processes require actin cytoskeletal remodeling to produce distinct F‐actin‐rich membrane structures called lamellipodia and phagocytic cups. This review will focus on the mechanisms by which macrophages regulate actin polymerization through initial receptor signaling and subsequent Arp2/3 activation by nucleation‐promoting factors like the WASP / WAVE family, followed by remodeling of actin networks to produce these very distinct structures.