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Micro RNA function in NK ‐cell biology
Author(s) -
Beaulieu Aimee M.,
Bezman Natalie A.,
Lee Jang Eun,
Matloubian Mehrdad,
Sun Joseph C.,
Lanier Lewis L.
Publication year - 2013
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12045
Subject(s) - biology , microrna , immune system , function (biology) , immunology , natural killer cell , cell function , inflammation , microbiology and biotechnology , cell , genetics , gene , cytotoxic t cell , in vitro
Summary The important role of micro RNA s in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific micro RNA s in regulating the development and function of natural killer ( NK ) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific micro RNA ablation in the settings of inflammation, infection, and immune dysregulation.