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A daunting task: manipulating leukocyte function with RNA i
Author(s) -
Peer Dan
Publication year - 2013
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12044
Subject(s) - rna interference , biology , function (biology) , computational biology , bioinformatics , microbiology and biotechnology , rna , genetics , gene
Summary RNA interference ( RNA i) has advanced into clinical trials. In spite of the progress made in systemic RNA i delivery to the liver and solid tumors, delivery of RNA i to leukocytes remains challenging and less advanced. Manipulating leukocyte function with RNA i holds great promise for streamlining the drug discovery process by facilitating in vivo drug target validation and for facilitating the development of RNA i‐based therapy platforms for leukocyte‐implicated diseases, such as blood cancer, inflammation, and leukocyte‐tropic viral infections. In this review, progress in delivery strategies of RNA i payloads to leukocytes, which are notoriously difficult cells to transduce with RNA i, is discussed with special emphasis on the challenges and potential opportunities for manipulating leukocyte function with RNA i.