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The role of mi RNA s in mast cells and other innate immune cells
Author(s) -
Montagner Sara,
Orlandi Ester M.,
Merante Serena,
Monticelli Silvia
Publication year - 2013
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12042
Subject(s) - biology , microrna , innate immune system , mast cell , microbiology and biotechnology , biogenesis , immune system , cell type , cell , immunology , genetics , gene
Summary MicroRNAs (mi RNA s) are a large class of small regulatory molecules able to control translation of target mRNA s and consequently to regulate various biological processes at a posttranscriptional level. Their importance is highlighted by the fact that altered mi RNA expression is linked to a variety of human diseases, particularly cancer. Accordingly, mi RNA biogenesis itself must be carefully regulated, both transcriptionally and posttranscriptionally. Here, we focus on the role of mi RNA s in three lineages of myeloid cells important in both innate and acquired immunity: mast cells, macrophages, and dendritic cells. These three cell types are strategically located throughout the body tissues, where they can respond to foreign material, danger, and inflammatory signals. We discuss the role of mi RNA s in these cell types, with a special focus on three of the most extensively studied mi RNA s, namely miR‐221, miR‐146a, and miR‐155. We also discuss the role of cell‐to‐cell transfer of mi RNA s in dendritic cells, mast cells, and macrophages, and we speculate about possible future directions in the field.