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CD 4 + T‐cell subsets in intestinal inflammation
Author(s) -
Shale Matthew,
Schiering Chris,
Powrie Fiona
Publication year - 2013
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/imr.12039
Subject(s) - immune system , inflammation , biology , immunology , effector , gastrointestinal tract , compartment (ship) , immunity , inflammatory bowel disease , t cell , disease , homeostasis , microbiology and biotechnology , medicine , pathology , biochemistry , oceanography , geology
Summary Intestinal CD 4 + T cells are essential mediators of immune homeostasis and inflammation. Multiple subsets of CD 4 + T cells have been described in the intestine, which represents an important site for the generation and regulation of cells involved in immune responses both within and outside of the gastrointestinal tract. Recent advances have furthered our understanding of the biology of such cells in the intestine. Appreciation of the functional roles for effector and regulatory populations in health and disease has revealed potential translational targets for the treatment of intestinal diseases, including inflammatory bowel disease. Furthermore, the role of dietary and microbiota‐derived factors in shaping the intestinal CD 4 + T‐cell compartment is becoming increasingly understood. Here, we review recent advances in understanding the multifaceted roles of CD 4 + T cells in intestinal immunity.