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Biological functions of IL‐17‐producing cells in mycoplasma respiratory infection
Author(s) -
Luo Ying,
Li Cheng,
Zhou Zhou,
Gong Zhande,
Zhu Cuiming,
Lei Aihua
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13346
Subject(s) - mycoplasma pneumoniae , immunology , mycoplasma , biology , pneumonia , immune system , respiratory system , lung , pneumonitis , mycoplasmataceae , inflammation , respiratory disease , microbiology and biotechnology , mollicutes , medicine , anatomy
Mycoplasmas are the smallest and simplest bacteria that lack a cell wall but have the capability of self‐replication. Among them, Mycoplasma pneumoniae is one of the most common causes of community‐acquired pneumonia. The hallmark of mycoplasma respiratory diseases is the persistence of lung inflammation that involves both innate and adaptive immune responses. In recent years, a growing body of evidence demonstrates that IL‐17 plays an important role in respiratory mycoplasma infection, and associates with the pathologic outcomes of infection, such as pneumonitis and asthma. Numerous studies have shown that a variety of cells, in particular Th17 cells, in the lung can secrete IL‐17 during respiratory mycoplasma infection. In this article, we review the biological functions of distinct IL‐17‐producing cells in mycoplasma respiratory infection with a focus on the effect of IL‐17 on the outcomes of infection.