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Hepatocyte CD1d protects against liver immunopathology in mice with schistosomiasis japonica
Author(s) -
Lei Zhigang,
Tang Rui,
Qi Qianqian,
Gu Pan,
Wang Junling,
Xu Lei,
Wei Chuan,
Pu Yanan,
Qi Xin,
Chen Ying,
Yu Beibei,
Yu Yanxiong,
Chen Xiaojun,
Zhu Jifeng,
Li Yalin,
Zhou Sha,
Su Chuan
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13288
Subject(s) - cd1d , biology , immunology , natural killer t cell , haematopoiesis , hepatocyte , immune system , schistosomiasis , t cell , stem cell , microbiology and biotechnology , biochemistry , helminths , in vitro
S. japonicum infection leads to a dramatic decrease in hepatocyte CD1d level, while overexpression of CD1d in hepatocytes significantly attenuates liver damage in infected mice. Our findings highlight the potential of hepatocyte CD1d‐targeted therapies for liver immunopathology control in schistosomiasis.