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A splice acceptor variant in HLA ‐ DRA affects the conformation and cellular localization of the class II DR alpha‐chain
Author(s) -
Didonna Alessandro,
Damotte Vincent,
Shams Hengameh,
Matsunaga Atsuko,
Caillier Stacy J.,
Dandekar Ravi,
Misra Maneesh K.,
Mofrad Mohammad R. K.,
Oksenberg Jorge R.,
Hollenbach Jill A.
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13273
Subject(s) - gene isoform , human leukocyte antigen , endoplasmic reticulum , alternative splicing , biology , microbiology and biotechnology , peptide , antigen , alpha chain , gene , biochemistry , genetics
The acceptor variant (rs8084) in the HLA‐DRA gene mediates the transcription of an alternative version of the alpha‐chain lacking 25 amino acids in its extracellular domain. This short isoform functions as a novel intact antigen for canonical class II HLA molecules.