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Tolerance induction in memory CD4 T cells is partial and reversible
Author(s) -
Gray Joshua I.,
AlKhabouri Shaima,
Morton Fraser,
Clambey Eric T.,
Gapin Laurent,
Matsuda Jennifer L.,
Kappler John W.,
Marrack Philippa,
Garside Paul,
Otto Thomas D.,
MacLeod Megan K.L.
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13263
Subject(s) - biology , antigen , immunology , t cell , antigen presenting cell , memory t cell , microbiology and biotechnology , immune system
We have examined the response of memory CD4 T cells to tolerogenic signals. Although memory CD4 T cells could respond to antigen delivered without adjuvant, they undergo cell death upon further restimulation. Our data suggest that the Tcells die as a consequence of mitotic catastrophe that occurs when cells are unable to complete cell division.