Premium
Candida albicans and candidalysin in inflammatory disorders and cancer
Author(s) -
Ho Jemima,
Camilli Giorgio,
Griffiths James S.,
Richardson Jonathan P.,
Kichik Nessim,
Naglik Julian R.
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13255
Subject(s) - candida albicans , cancer , biology , corpus albicans , microbiology and biotechnology , human health , human pathology , immunology , medicine , disease , pathology , genetics , environmental health
Summary As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.