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MicroRNA‐7 negatively regulates Toll‐like receptor 4 signaling pathway through FAM177A
Author(s) -
Chen Huizi,
Guo Mengmeng,
Yue Dongxu,
Zhao Juanjuan,
Zhou Ya,
Chen Chao,
Liang Guiyou,
Xu Lin
Publication year - 2021
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13252
Subject(s) - tlr4 , signal transduction , microbiology and biotechnology , biology , microrna , toll like receptor , suppressor of cytokine signalling , receptor , signalling , innate immune system , gene , genetics , stat3 , socs3
In the present study, we found that miR‐7 expression in TLR4 signalling‐activated bone marrow‐derived macrophages (BMDMs) stimulated by LPS was dramatically increased. Importantly, miR‐7 deficiency significantly enhanced the production of related inflammatory cytokines including IL‐1β, IL‐6 and IL‐12, as well as TNF‐α, on LPS‐activated BMDMs, accompanied by elevated transduction of TLR4 signalling including Myd88‐dependent and Myd88‐independent pathways. Mechanistically, we identified family with sequence similarity 177, member A (FAM177A) as a novel target molecule of miR‐7.