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Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data
Author(s) -
Toufiq Mohammed,
Roelands Jessica,
Alfaki Mohamed,
Syed Ahamed Kabeer Basirudeen,
Saadaoui Marwa,
Lakshmanan Arun Prasath,
Bangarusamy Dhinoth Kumar,
Murugesan Selvasankar,
Bedognetti Davide,
Hendrickx Wouter,
Al Khodor Souhaila,
Terranegra Annalisa,
Rinchai Darawan,
Chaussabel Damien,
Garand Mathieu
Publication year - 2020
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13239
Subject(s) - sepsis , transcriptome , biology , annexin , downregulation and upregulation , phagosome , clinical significance , inflammation , in vivo , immunology , apoptosis , microbiology and biotechnology , bioinformatics , medicine , gene expression , gene , pathology , phagocytosis , flow cytometry , genetics
The expression of Annexin A3 (ANXA3), a member of a family of calcium‐binding proteins, is restricted to neutrophils. Its abundance is increased in septic patients, yet the functional relevance of ANXA3 in this context remains unknown. Upon reviewing evidence from public transcriptome repositories and the literature, we hypothesize that during sepsis ANXA3 could mediate neutrophils microbicidal activity while also prolonging their survival, and thus also possibly contributing to organ damage.