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Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5
Author(s) -
Zelek Wioleta M.,
Menzies Georgina E.,
Brancale Andrea,
Stockinger Brigitta,
Morgan Bryan Paul
Publication year - 2020
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13228
Subject(s) - anaphylatoxin , monoclonal antibody , complement system , eculizumab , complement component 5 , antibody , complementarity determining region , biology , blocking antibody , computational biology , microbiology and biotechnology , immunology
The work provides a mechanistic basis for the activities of this landmark antibody BB5.1, a much‐used tool that was a major impetus to the development of anti‐complement drugs for human disease.