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Depletion of langerin + cells enhances cutaneous wound healing
Author(s) -
Rajesh Aarthi,
Stuart Gabriella,
Real Nicola,
Ahn Jenny,
Tschirley Allison,
Wise Lyn,
Hibma Merilyn
Publication year - 2020
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13202
Subject(s) - langerin , wound healing , granulation tissue , immunology , biology , birbeck granules , microbiology and biotechnology , epidermis (zoology) , immune system , dendritic cell , langerhans cell , anatomy
Summary Langerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin + cells in wound healing. In this study, the effects of ablation of langerin + cells on healing of a full‐thickness excision wound were investigated using the langerin‐DTR depletable mouse. Strikingly, depletion of langerin + cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin + ‐cell‐depleted group was characterized by enhanced neo‐epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin + cells was associated with increased levels of granulocyte–macrophage colony‐stimulating factor, F4/80 + cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin + cells during wound healing. Therapies that suppress langerin + cells or their function may therefore have utility in progressing the healing of wounds in humans.