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The role of B cells in the immunopathogenesis of multiple sclerosis
Author(s) -
Gharibi Tohid,
Babaloo Zohreh,
Hosseini Arezoo,
Marofi Faroogh,
Ebrahimikalan Abbas,
Jahandideh Saeed,
Baradaran Behzad
Publication year - 2020
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13198
Subject(s) - immunology , antibody , pathogenesis , multiple sclerosis , antigen presentation , b cell , antigen , regulatory b cells , myeloid cells , antigen presenting cell , biology , function (biology) , myeloid , t cell , medicine , immune system , microbiology and biotechnology
Summary There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells, particularly the antibody‐independent functions of these cells such as antigen presentation to T cells and modulation of the function of T cells and myeloid cells by secreting pathogenic and/or protective cytokines in the central nervous system. Here, we discuss the role of different antibody‐dependent and antibody‐independent functions of B cells in MS disease activity and progression proposing new therapeutic strategies for the optimization of B‐cell targeting treatments.