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‘Just 17 if you know what I mean’ … but what do we really mean to say about Th17 immunity?
Author(s) -
Altmann Daniel M.
Publication year - 2019
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13055
Subject(s) - immunity , immunology , acquired immune system , biology , innate immune system , cytokine , innate lymphoid cell , immune system
Summary Th17‐derived IL ‐17 might be considered the archetypal pro‐inflammatory cytokine of adaptive immunity, to be targeted by new therapeutics for alleviation of autoimmune and inflammatory disease. However, the IL ‐17 family of cytokines is produced by diverse innate and adaptive cells, including Th17, Tc17, ILC 3, NK cells and γδ T‐cells. These responses are appreciated to underpin diverse aspects of protective, physiological immunity, from dialogue with the gut microbiota to bacterial and fungal immunity in the lung.