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Recent advances on the crosstalk between neutrophils and B or T lymphocytes
Author(s) -
Costa Sara,
Bevilacqua Dalila,
Cassatella Marco A.,
Scapini Patrizia
Publication year - 2019
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.13005
Subject(s) - crosstalk , biology , immune system , acquired immune system , immunology , inflammation , pathological , spleen , homeostasis , lymph , immunity , microbiology and biotechnology , medicine , pathology , physics , optics
Summary An increasing body of literature supports a role for neutrophils as players in the orchestration of adaptive immunity. During acute and chronic inflammatory conditions, neutrophils rapidly migrate not only to sites of inflammation, but also to draining lymph nodes and spleen, where they engage bidirectional interactions with B‐ and T‐lymphocyte subsets. Accordingly, a relevant role of neutrophils in modulating B‐cell responses under homeostatic conditions has recently emerged. Moreover, specialized immunoregulatory properties towards B or T cells acquired by distinct neutrophil populations, originating under pathological conditions, have been consistently described. In this article, we summarize the most recent data from human studies and murine models on the ability of neutrophils to modulate adaptive immune responses under physiological and pathological conditions and the mechanisms behind these processes.