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Human CD 8 T‐cell activation in acute and chronic chikungunya infection
Author(s) -
Dias Cinthia Nóbrega de Sousa,
Gois Bruna Macêdo,
Lima Viviane Silva,
GuerraGomes Isabel Cristina,
Araújo Josélio Maria Galvão,
Gomes Juliana de Assis Silva,
Araújo Demétrius Antônio Machado,
Medeiros Isac Almeida,
Azevedo Fátima de Lourdes Assunção Araújo de,
Veras Robson Cavalcanti,
Janebro Daniele Idalino,
Amaral Ian Porto Gurgel do,
Keesen Tatjana Souza Lima
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12992
Subject(s) - perforin , cd8 , granzyme b , immunology , ex vivo , immune system , biology , chikungunya , granzyme , cytotoxic t cell , fas ligand , virology , in vivo , virus , in vitro , apoptosis , biochemistry , microbiology and biotechnology , programmed cell death
Summary There is a need for more detailed elucidation of T‐cell immunity in chikungunya infection. CD 8 T cells are one of main actors against viruses. Here, we analysed CD 8 + T lymphocytes from patients in the acute and chronic phases of chikungunya disease ( CHIKD ). Our results demonstrate that CD 8 + T cells expressed higher ex vivo granzyme B, perforin and CD 107A expression in patients in the acute phase of CHIKD compared with healthy individuals and higher ex vivo expression of CD 69, interleukin‐17A, interleukin‐10 and CD 95 ligand, and co‐expression of CD 95/ CD 95 ligand. These results elucidate the importance of these lymphocytes, demonstrating immune mechanisms mediated in human chikungunya infection.